Sex determination in most organisms involves a simple binary fate choice between male or female development; the outcome of this decision has profound effects on organismal biology, biochemistry and behaviour. In the nematode C. elegans, there is also a binary choice, either male or hermaphrodite. In C. elegans, distinct genetic pathways control somatic and germline sexual cell fate. Both pathways share a common set of globally acting regulatory genes; however, germline-specific regulatory genes also participate in the decision to make male (...) or female gametes. The determination of sexual fate in the germline of the facultative hermaphrodite poses a special problem, because first sperm then oocytes are produced. It has emerged that additional layers of post-transcriptional regulation have been imposed to modulate the activities of the global sex-determining genes, tra-2 and fem-3; the balance between these activities is crucial in controlling sexual cell fate in the hermaphrodite germline. BioEssays 23:596–604, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This paper interprets and analyzes the debate having taken place in 1995 between E. Gellner and A. Smith concerning the problem of the emergence of nations. This discussion is used as an example to show the basic general features of two approaches in theories of nationalism - the modernist and the ethno symbolic ones. Pointing to the common assumptions shared by Gellner's and Smith's theories of nations, the author interprets ethno-symbolism as a sort of internal self-criticism of the modernist standpoint. (...) This polemic is therefore interpreted not as a debate between "creationist" and "evolutionist" solutions to the problem of the emergence of nations, but rather as a debate between two theoretical paradigms defining different research priorities in studying nations and nationalisms. From this perspective, the author concludes that the ethno symbolic approach to the genealogy of nations has broader heuristic capacities than the modernist paradigm, at least when the emergence of "peripheral nations" and the understanding of the dynamic of their nationalisms are concerned. U radu je interpretiran i analiziran spor koji su vodili E. Gelner i A. Smit 1995. godine o problemu nastanka nacija. Na primenu ove diskusije prikazane su osnovne opste karakteristike dva pristupa u teorijama nacionalizma modernistickog i etnosimbolickog. Ukazujuci na zajednicke pretpostavke Gelnerove i Smitove teorije nacija, autor je etnosimbolizam tumacio kao jednu vrstu unutrasnje samokritike modernistickog stanovista. Na taj nacin, ova polemika nije interpretirana kao spor izmedju "kreacionistickog" i "evolucionistickog" resenja problema nastanka nacija, vec prevashodno kao spor dve teorijske paradigme koje razlicito odredjuju istrazivacke prioritete u tematizaciji nacija i nacionalizama. Sa tog stanovista, autor je zakljucio da etnosimbolicki pristup genealogiji nacija ima vece heuristicke kapacitete od modernisticke paradigme, bar kada je u pitanju problem nastanka "perifernih nacija " i razumevanja dinamike njihovih nacionalizama. (shrink)

Zkoumání je založeno na reflexi sémantického pojetí vědec- kých teorií Ronalda Giera. Gierova východiska a závěry jsou podrobeny kritice, na jejímž základě autor buduje svou vlastní variantu modelově založeného pojetí teorií. Hlavním cílem příspěvku je konceptualizace vztahu mezi principy a modely s důrazem na to, že tento vztah může zakládat dynamiku teorie, respektive posloupnosti teorií. Souhrnně bude v příspěvku prověřována řada tezí: 1) Základními prvky teorie jsou modely, které slouží jako nosiče principů. 2) Modely hrají rozhodující roli při pojmové výstavbě (...) teorie. 3) Modely artikulací principů odhalují poznatky, které ze samotných principů neplynou. 4) Principy mohou být někdy souhrnně definovány až poté, co existuje odpovídající množina modelů. 5) Nová teorie nastoupí ve chvíli, kdy je cluster nových modelů dostatečně komplexní a když si vědecké společenství ujasní, že tento nový cluster je založen na určité množině nových principů. (shrink)

Petrić, koji na Pletonovu tragu spise poznate pod naslovom Kaldejska proroštva pripisuje Zoroastru, »suvremeniku Abrahamovu, prvom otkrivaču astrologije i magije tj. mudrosti«, objavljuje te spise u »Dodatku« svoje Nove sveopće filozofije 1591. te 1593. godine pod naslovom Zoroaster et eius CCCXX Oracula Chaldaica, eius opera e tenebris eruta et latine reddita . Spisi će 1593. godine kao zasebno izdanje biti objavljeni u Hamburgu pod naslovom Magia philosophica hoc est Zoroaster et eius CCCXX Oracula chaldaica .Zoroastru pripisanu filozofiju Petrić zajedno sa (...) svojom vlastitom i s još tri filozofije, kao jednu »pobožnu filozofiju« podastire papi Grguru XIV. u zamjenu za Aristotelovu »bezbožnu « filozofiju što se »posvuda predaje po školama«.Prema njegovim vlastitim riječima, Petrić ulaže »nemali trud« u prikupljanje 324 stiha Kaldejskih proroštava, raspršenih po djelima različitih autora poglavito novoplatoničke orijentacije, sakupljajući ih u jedan cjelovit spis, koji raspoređuje u nekoliko tematskih cjelina i prevodi na latinski.U tekstu se nastoje sagledati Petrićevi motivi izdavanja Zoroastru pripisanih Oracula chaldaica, što se povezuje prije svega s pitanjem o tome jesu li i, ako jesu, kako su učenja iz Oracula prisutna u njegovoj vlastitoj filozofiji izloženoj u Novoj sveopćoj filozofiji.Svoj načelni stav o tome kako Proroštva funkcioniraju u njegovoj filozofiji iznosi Petrić u šestoj knjizi »Panarchije« Nove sveopće filozofije gdje kaže: »Ali mi filozofiramo pozivajući se na autoritete [pri čemu misli prije svega na Zoroastra] više kao na ures nego kao na temelj. Pozabavimo se stoga dokazima!« Premda, naime, Zoroastra priznaje kao autoritet, Petrić njegove izrijeke ne smatra filozofskim dokazima!Analizom Nove sveopće filozofije pokušava se u tekstu doći do odgovora na pitanje stoji li ova Petrićeva tvrdnja o pozivanju na autoritete kao na ures. Ujedno se nastoji sagledati specifičnost njegove interpretacije Kaldejskih proroštava, napose interpretacije koncepcije počela u njima izložene.Na kraju su značajke Petrićeve recepcije tih spisa rezimirane u jednoj njegovoj izjavi, vezanoj doduše uz pitanje razuma, no koja se može primijeniti i na sva ostala učenja izložena u Oracula chaldaica. Petrić u njoj znakovito kaže: »Međutim ta [sc. Zoroastrova] povijest o razumu ne čini se da se mnogo tiče naše filozofije, niti se pak mnogo razlikuje od nje.«The article attempts to examine Petrić’s motives for publishing Oracula Chaldaica, attributed to Zoroaster, and relate them primarily with the question of whether the teachings from the Oracles are present, and if so, in what way are they present in Petrić’s philosophy laid out in his Nova de universis philosophia.Petrić introduces his basic position on how Oracles function in his philosophy in the sixth book of “Panarchia” in Nova de universis philosophia, where he says: “But we philosophise by appealing to the authorities [by which he primarily means Zoroaster] more in the sense of an ornament than in the sense a foundation. Let us therefore deal with proofs!” Although, in fact, Petrić recognizes Zoroaster as an authority, he does not regard his sayings as philosophical proofs!Through the analysis of Nova de universis philosophia the article tries to answer the question whether the claim of appealing to the authorities merely as an ornament is justified. At the same time, it tries to expound the particularity of his interpretation of Chaldean Oracles, especially the interpretation of the notion of substance found in Oracles.Finally, the features of Petrić’s reception of these writings are summarized in one of his statements, although connected to the issue of reason, but which can be applied to all of the teachings of Oracula Chaldaica. He indicatively states: “However, this [sc. Zoroaster’s] history of reason does not seem to concern our philosophy very much, nor does it greatly differ from it.”. (shrink)

Aspiracija za jedinstvenim upravljanjem svetom je stara koliko i sam svet. Ona u suštini proizlazi iz naše percepcije sveta kao jednog, bez obzira na sve razlike koje se u njemu takođe vide. U naše vreme ova percepcija je pojačana utiskom o sve većoj međuzavisnosti delova sveta, kao i osećajem da su razlike, ma koliko bile velike, sve manje važne u odnosu na ono što je isto ili bar slično u različitim delovima sveta. Ovaj osećaj jedinstva je još više pojačan percepcijom (...) potrebe, ili nužde, da se o važnim stvarima u svetu odlučuje i upravlja na jedinstven način, bez kolizija koje bi proces odlučivanja učinile neefikasnim ili nemogućim. Ali jedinstvo sveta bi trebalo da u sebi sadrži ideju ravnopravnosti, i neke načelne jednakosti. Međutim, uvidom u način na koji se ovaj proces unifikacije sveta stvarno odvija vidimo mnoge probleme. Neki od njih su za očekivati – problemi reprezentacije i pristanka na svetsku vlast koja bi bila odraz jedinstvene zakonodavne volje čovečanstva. Takva volja možda uopšte ne može da se konstituiše. Umesto nje imamo volju za hegemonijom koju prati ideja nejednakosti i manihejske podele sveta na naš i tuđi deo, kao i razne vrste pokušaja ukidanja onog uslova koji svakom zakonodavstvu daje njegov legitimet – a to je sloboda. Suočavamo se sa idejom da je, kao uslov mira i demokratije (šta god da to znači, ili što će značiti u bližoj i daljoj budućnosti) potrebno uspostaviti krutu nejednakost i rigidnu kontrolu svih različitosti u jednom zamrznutom stanju podele na povlašćene i obezvlašćene, na „dobre“ i „loše“ momke, kao da se svet sastoji od „momaka“. Ključni deo ove sheme je pretpostavka o univerzalnoj samerljivosti svega što život čini vrednim. Ta pretpostavka uniformiše i simplifikuje, smanjuje, svet, negirajući relevanciju i stvarnost razlikama koji sada predstavljaju stvarnost sveta. Zakoni više ne pretpostavljaju postojanje zakonodavne volje. U toj situaciji proizvodnja ogromne količine iluzorne sreće više liči na podmićivanje svetskog lumpenproletarijata, sa rizikom da celokupno čovečanstvo postane totalno ravnodušno prema svakoj posebnosti i svakoj vrlini, sasvim primereno svojoj novoj lumpenproleterskoj prirodi. (shrink)

In diesem Texte werden die Kriterien zur Differenzierung von historischen, politischen und heroischen Generationen und ihren Hauptarten in USA, BR Deutschland, China, Serbien und Croatien er?rtert. Kriege und Revolutionen werden als zentrale generationsschaffende Ereignisse markiert. Es werden auch die konstruierten wie auch zugeschriebenen Generationsidentit?tsarten dargestellt. Die Generation ist als eine mehr oder wenig klare Gruppe aufgefa?t, die durch Zusammensetzung von biographischem und kollektivem Ged?chtnis entstanden ist. Die Generation als eine Art von Zeitstruktur ist bei der Reduktion und Erkl?rung der Vergangenheit (...) anwendbar. Es ist immer eine offene Frage in welchem Masse die Generationen die realen handelnden Subjekte, oder blo?e symbolische Heimat, dh. eine durchg?ngige Erinnerungsgemeinschaft sind? Es wird auf die Gr?nden der Entstehung der balkanischen heroischen Generationen hingewiesen, auf ihre Natur und Aktualit?t. In Westeuropa ist diese Art von Generation schon lange nicht mehr aktuell. Es wird auch darauf hingewiesen, dass durch die Heroisierung einer Generationserfahrung die Herrschaftsgruppen eigene Werte oktroyieren k?nnen. Razmotreni su kriteriji razlikovanja istorijskih, politickih i herojskih generacija i prikazani njihovi konkretni primeri u SAD, SR Nemackoj, NR Kini Srbiji i Hrvatskoj. Ratovi i revolucije su uoceni kao glavni generacijski formativni dogadjaji, ali su prikazani i oblici konstruisanog i pripisanog generacijskog samoopisa. Generacija je rastumacena kao manje ili vise prepoznatljiva grupa formirana prozimanjem biografskog i kolektivnog pamcenja. Kao jedna od kategorija u mrezi slozenih vremenskih struktura generacija je korisna kod redukovanja i objasnjenja slozenosti proslosti. Otvoreno je pitanje koliko su generacije realni akteri promena, a koliko tek simbolicki vremenski zavicaj, tj. efemerna zajednica secanja? Blize su analizirani uzroci nastanka, priroda i aktuelnost balkanskih herojskih generacija. U Zapadnoj Evropi ova vrsta generacija odavno nije aktuelna. Uoceno je da se heroizacijom iskustva jedne generacije mogu uspesno nametati vrednosti vladajucih grupa. (shrink)

Tato studie se zabývá zobrazováním alchymie v malbách, knižních ilustracích i v architektuře v období raného novověku. Na jednotlivých příkladech obrazů či ilustrací prezentuje různé aspekty alchymistova života i jeho práce. Nezabývá se symbolickou alchymickou ikonografií, ale zaměří se především na zobrazování prostředí a vybavení alchymických dílen i osobností samotných alchymistů. Soustředí se zejména na vyobrazení zařízení alchymických laboratorií, s nimiž se lze setkat jak u renesančních malířů, tak v ilustracích alchymických rukopisů a poměrně ojediněle i v české architektuře. Poskytuje (...) také pohled na vyobrazení vzniklá v souvislosti s literární kritikou alchymie. Alchymisté byli zejména v dílech předních evropských humanistů často záměrně zesměšňováni, kritizováni a označováni za blázny a zloděje. V závěru se zabývá vybranými příklady ze žánrového umění, kde byli rovněž alchymisté zobrazováni často satiricky, ale i s určitou úctou, jako vzdělaní učenci. Výtvarné umění raného novověku nám představuje různé aspekty života alchymistů a je v dnešní době jednou z možností, jak se přiblížit porozumění jejich vědeckým aktivitám. Jak však studie ukazuje, k těmto obrazovým materiálům je třeba přistupovat kriticky. (shrink)

The sudden emergence of the COVID-19 pandemic brought global disruption to every aspect of society including healthcare, supply chain, the economy, and social interaction. Among the many emergent considerations were the safety and public health of the public, patients, essential workers, and healthcare professionals. In certain locations, clinical research was halted—or terminated—in deference to the immediate needs of patient care, and clinical trials focusing on the treatment and prevention of coronavirus infection were prioritized over studies focusing on other diseases. Difficult (...) decisions were made rapidly; flexibility and reconsideration were necessary not only because the intensity and severity of infection varied over time and by locale but also because knowledge of the disease and understanding of its treatment grew. Here we discuss the ethical challenges in decision-making and competing ethical tensions during the pandemic in an effort to advance future preparedness. (shrink)

Linguistic study of Mongolian traditional classical translation.

Context: In the digital era, it is important to investigate the potential impact of digital technologies in education and how such tools can be successfully integrated into the mathematics classroom. Similarly to many others in the constructionism community, we have been inspired by the idea set out originally by Papert of providing students with appropriate “vehicles” for developing “Mathematical Ways of Thinking.” Problem: A crucial issue regarding the design of digital tools as vehicles is that of “transfer” or “bridging” i.e., (...) what mathematical knowledge is transferred from students’ interactions with such tools to other activities such as when they are doing “paper-and-pencil” mathematics, undertaking traditional exam papers or in other formal and informal settings. Method: Through the lens of a framework for algebraic ways of thinking, this article analyses data gathered as part of the MiGen project from studies aiming at investigating ways to build bridges to formal algebra. Results: The analysis supports the need for and benefit of bridging activities that make the connections to algebra explicit and for frequent reflection and consolidation tasks. Implications: Task and digital environment designers should consider designing bridging activities that consolidate, support and sustain students’ mathematical ways of thinking beyond their digital experience. Constructivist content: Our more general aim is to support the implementation of digital technologies, especially constructionist learning environments, in the mathematics classroom. (shrink)

Spinoza's writings on metaphysics, ethics, and politics have had a remarkably diverse reception in recent times and have contributed to the current dialogue among philosophers, intellectual historians, and literary theorists.Errol E. Harris has written a brief and simplified introductory presentation of the major branches of Spinoza's philosophy. Spinoza's ideas are put forward in plain language and supported by convincing argument. Technicalities are either clearly explained or entirely avoided. Professor Harris also shows the student how Spinoza succeeded in reconciling the insights (...) of both the British empiricists and the continental rationalists.Errol E. Harris (Ambleside, Cumbria, England) is John Evans Professor of Moral and Intellectual Philosophy (Emeritus) at Northwestern University, and the author of Fundamentals of Philosophy, Spinoza's Philosophy: An Outline, The Substance of Spinoza, The Foundations of Metaphysics in Science, Hypothesis and Perception, Cosmos and Anthropos: A Philosophical Interpretation of the Anthropic Cosmological Principle, Cosmos and Theos: Ethical and Theological Implications of the Anthropic Cosmological Principle, and One World or None: Prescription for Survival. (shrink)

In the final chapter of his recent book How to Be a Pyrrhonist: The Practice and Significance of Pyrrhonian Skepticism, Richard Bett discusses the possibility of living as a Pyrrhonian skeptic today. Chief among his concerns is the scope of the skeptic’s suspension of judgment and whether or not the skeptic could maintain suspension of judgment in light of the results of modern science. For example, how might the skeptic sustain suspension of judgment in light of overwhelming evidence for climate (...) change? Or even atomic theory? Ultimately, Bett concludes that such claims within the natural sciences preclude us from living as Pyrrhonists today. In the following paper I argue, how it is possible for the Pyrrhonian skeptic to suspend judgment on certain well-confirmed scientific theories, how the skeptic does so in accord with rational norms, and in turn, that Pyrrhonian skepticism is possible as a way of life today. (shrink)

The volume discusses the key documents, authors, themes and Early Christian traditions in succinct articles by eminent experts (including the Editors). The main 6 sections of the volume trace the vital trajectories of emerging distinctive Christian identity in the Graeco-Roman world and diversities of theologies. Special attention is given to the coherent growth of Christian faith in connection with worship, alongside the crucial transformation of Christian life and doctrine under the Christian Emperor. In addition, readers interested in systematic theology are (...) offered chapters on the roots of some significant theological notions in Christian Antiquity, also with reference to ancient philosophy. The team of editors invited leading scholars from various international academic centres to contribute their comments based on their research and teaching. The book finishes with appendices and indexes giving information on biblical references, updated publications, electronic resources and classified bibliographies. (shrink)

Foucault’s remarks concerning psychoanalysis are ambivalent and even prima facie contra-dictory, at times lauding Freud and Lacan as anti-humanists, at others being severely criti-cal of their imbrication within psychiatric power. This has allowed a profusion of interpretations of his position, between so-called ‘Freudo-Foucauldians’ at one extreme and Foucauldians who condemn psychoanalysis as such at the other. In this article, I begin by surveying Foucault’s biographical and theoretical relationship to psychoanalysis and the sec-ondary scholarship on this relationship to date. I pay (...) particular attention to the discussion of the relationship in feminist scholarship and queer theory, and that by psychoanalytic thinkers, as well as attending to the particular focus in the secondary literature on Fou-cault’s late work and his relationship to the figure of Jacques Lacan. I conclude that Fou-cault’s attitude to psychoanalysis varies with context, and that some of his criticisms of psychoanalysis in part reflect an ignorance of the variety of psychoanalytic thought, partic-ularly in its Lacanian form. I thus argue that Foucault sometimes tended to overestimate the extent of the incompatibility of his approach with psychoanalytic ones and that there is ultimately no serious incompatibility there. Rather, psychoanalysis represents a substantively different mode of inquiry to Foucault’s work, which is neither straightforwardly ex-clusive nor inclusive of psychoanalytic insights. (shrink)

Providing efficient and clean power is a challenge for devices that range from the micro to macro in scale. Although there has been significant progress in the development of micro-, meso-, and macro-scale power supplies and technologies, realization of many devices is limited by the inability of power supplies to scale with the diminishing sizes of CMOS-based technology. Here, the authors provide an overview of piezoelectric energy harvesting technology along with a discussion of proof of concept devices, relevant governing equations, (...) and figures of merit. They present two case studies: (a) energy capture from the operation of a novel shear and elastic modulus indentation device subjected to applied voltage and (b) energy capture from vibrating commercial bimorph piezoelectric structures mounted on household appliances. Lastly, areas of development needed for realization of commercial energy harvesting devices are suggested. (shrink)

E. Rae Harcum argues that Christians do not have to give up their religious faith to keep the contributions of science. He confronts the relation between the human body and its non-material parts—the mind and spirit—and provides a way of looking at these metaphysical issues.

Four critical essays (on De Anima, on In Illud: Tunc et Ipse Filius, on Patristic Platonism, and on the doctrine of apokatastasis in Gregory of Nyssa and Origen), new Greek edition of De anima also based on the Coptic version predating every Greek manuscript, translations of, and commentaries on, both De Anima and In Illud: Tunc et Ipse Filius, appendixes (on the Syriac and Coptic translations of De Anima and on its reception among the Cambridge Platonists, with the first Italian (...) translation of an essay by Jane Lead[e]), bibliographies. (shrink)

I believe that the world is a totality of things: there are no properties, or relations, or sets, or states of affairs, or facts, or events; there are only particular things. I also believe that all true statements can be expressed in a canonical language which includes names of things and logical terms only: there will be no predicates in this language. For what is a predicate? Some say that predicates are names of universals which individual things exemplify, or names (...) of sets of which individual things are members. If this is so, it is obvious that a nominalist's canonical language cannot have any predicates. Others say that predicates name nothing, but are satisfied by particular things. What, however, is satisfaction, and how is it different from naming? Semantic relations such as satisfaction, we are told, are not ‘in’ the world. But then a nominalist has no use for them. (shrink)